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MSc-PGDip in Applied Toxicology

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  • Objectives
    This part-time modular training programme is designed to provide in-post scientists with the opportunity to obtain advanced training and a higher qualification in toxicology. Participants include employees in government departments, contract laboratories and pharmaceutical, chemical and consumer product industries. The programme aims to enhance understanding of the underlying scientific disciplines involved in toxicology, the mechanisms of action of various types of toxic agent and the application of toxicology to meet regulatory requirements. The Postgraduate Diploma requires the successful completion of the eight core modules and one supplementary module from a wide range of options. The MSc requires successful completion of either an additional three supplementary modules or a dissertation. Each module is an intensive programme over five days, preceded by pre-module reading. The eight core modules are scheduled in a two-year cycle accompanied by a selection of supplementary modules per year. Each module is assessed by a written examination and a home assignment to be completed within ten weeks of the module. An integrative, non-credit bearing, final assessment is undertaken after completion of the eight core modules.
  • Entry requirements
    Entry Requirements BSc or equivalent, or a technical qualification with suitable work experience. Evidence of the required qualifications, two written references and satisfactory completion of one module is required before acceptance for registration for the MSc/Postgraduate Diploma. The language of instruction is English, and proficiency in English is a prerequisite.
  • Academic Title
    MSc/PGDip in Applied Toxicology
  • Course description
    MSc/PGDip in Applied Toxicology Module overview
    The programme comprises eight core modules and a number of supplementary modules. A minimum of four core modules are offered in alternate years.

    Core Modules

    Carcinogenicity and Mutagenicity

    The aim of this module is to provide the student with the knowledge to be able to assess carcinogenicity study reports in the context of overall toxicological evaluation.

    Principles of Experimental Toxicology and Risk Assessment
    This module takes a critical approach to the conduct and interpretation of toxicity studies, emphasising the need to employ a flexible approach in order to maximise understanding of the underlying mechanisms of toxicity and their relevance to human risk assessment.

    Principles of Toxicological Pathology
    This module introduces the principles of pathology, including the preparation and examination of tissues from toxicity studies.

    Reproductive Toxicology
    This module aims to provide the student with an understanding of a broad spectrum of topics on reproductive toxicology using a multidisciplinary approach to risk assessment.

    Target Organ Toxicology (3 modules)
    These modules examine the pathology, anatomy, physiology and toxicology of the liver, kidney, GI tract, skin, CNS, PNS, endocrine organs, musculoskeletal, cardiorespiratory and haematopoietic systems. Each module provides an understanding of the mechanisms of action of substances on target systems to enable interpretation of data from effects observed in these systems.

    Toxicokinetics and Metabolism
    A good knowledge of the principles of xenobiotic metabolism is central to toxicology because many compounds undergo enzymic metabolism to form toxic metabolites. Toxicokinetics is the study of the rates of absorption, distribution, metabolism and excretion of toxicants and is central to an understanding of the exposure of target tissues to toxicants. This module focuses on toxicokinetics and xenobiotic metabolism with particular emphasis on risk assessment.

    Supplementary Modules

    -Alternative Methodologies to the Use of Animals in Toxicology
    -Bioinformatics and '-omics'
    -Dermal Toxicology
    -Design of In Vivo Studies
    -Endocrine System
    -Food Chemical Safety Evaluation
    -Haematology and Clinical Biochemistry
    -Inhalation Toxicology
    -Lesions, Repair and Mutations
    -Measuring and Interpreting Responses - Numerical and Human Health Data
    -Metabolism and Human Variation
    -Occupational Toxicology
    -Paediatric Toxicology
    -Plant Protection Products and Plant Biotechnology
    -Safety Assessment of Pharmaceutical Agents
    -Safety Pharmacology in Preclinical R and D
    -Study Design, Quality and Interpretation
    -Techniques in Safety Assessment

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